Occupying the historic Fayette National Bank Building downtown, 21c Museum Hotel Lexington is an 88-room boutique hotel, art museum, & home to Lockbox restaurant. With 7,000 square feet of exhibition space featuring site-specific installations & rotating exhibits, there’s always something new to discover. The rooms offer contemporary furnishings, high ceilings, and large historic windows. Lockbox, in the original vault, highlights Kentucky’s produce through chef Stephen Holden’s refined style.